Diffusivelike Motions in a Solvent-Free Protein-Polymer Hybrid - Université Grenoble Alpes Accéder directement au contenu
Article Dans Une Revue Physical Review Letters Année : 2021

Diffusivelike Motions in a Solvent-Free Protein-Polymer Hybrid

Résumé

The interaction between proteins and hydration water stabilizes protein structure and promotes functional dynamics, with water translational motions enabling protein flexibility. Engineered solvent-free protein-polymer hybrids have been shown to preserve protein structure, function, and dynamics. Here, we used neutron scattering, protein and polymer perdeuteration, and molecular dynamics simulations to explore how a polymer dynamically replaces water. Even though relaxation rates and vibrational properties are strongly modified in polymer coated compared to hydrated proteins, liquidlike polymer dynamics appear to plasticize the conjugated protein in a qualitatively similar way as do hydration-water translational motions.
Fichier principal
Vignette du fichier
PhysRevLett.126.088102.pdf (707.07 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03185091 , version 1 (25-11-2022)

Identifiants

Citer

Giorgio Schirò, Yann Fichou, Alex Brogan, Richard Sessions, Wiebke Lohstroh, et al.. Diffusivelike Motions in a Solvent-Free Protein-Polymer Hybrid. Physical Review Letters, 2021, 126 (8), pp.088102. ⟨10.1103/PhysRevLett.126.088102⟩. ⟨hal-03185091⟩
43 Consultations
36 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More