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Article dans une revue

Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: Dependence upon both fluxes and forces

Abstract : The purpose of this work was to show how the quantitative definition of the different parameters involved in mitochondrial oxidative phosphorylation makes it possible to characterize the mechanisms by which the yield of ATP synthesis is affected. Three different factors have to be considered: (i) the size of the different forces involved (free energy of redox reactions and ATP synthesis, proton electrochemical difference); (ii) the physical properties of the inner mitochondrial membrane in terms of leaks (H+ and cations); and finally (iii) the properties of the different proton pumps involved in this system (kinetic properties, regulation, modification of intrinsic stoichiometry).
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Article dans une revue
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https://hal.univ-grenoble-alpes.fr/hal-01989720
Contributeur : Sarah Hamant <>
Soumis le : mardi 22 janvier 2019 - 15:14:11
Dernière modification le : mercredi 15 juillet 2020 - 09:10:04

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  • HAL Id : hal-01989720, version 1

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Michel Rigoulet, Xavier Leverve, Eric Fontaine, Rachid Ouhabi, Bernard Guérin. Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: Dependence upon both fluxes and forces. Molecular and Cellular Biochemistry, Springer Verlag, 1998, 184 (1-2), pp.35-52. ⟨hal-01989720⟩

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