Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: Dependence upon both fluxes and forces - Université Grenoble Alpes
Article Dans Une Revue Molecular and Cellular Biochemistry Année : 1998

Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: Dependence upon both fluxes and forces

Résumé

The purpose of this work was to show how the quantitative definition of the different parameters involved in mitochondrial oxidative phosphorylation makes it possible to characterize the mechanisms by which the yield of ATP synthesis is affected. Three different factors have to be considered: (i) the size of the different forces involved (free energy of redox reactions and ATP synthesis, proton electrochemical difference); (ii) the physical properties of the inner mitochondrial membrane in terms of leaks (H+ and cations); and finally (iii) the properties of the different proton pumps involved in this system (kinetic properties, regulation, modification of intrinsic stoichiometry).
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Dates et versions

hal-01989720 , version 1 (22-01-2019)

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  • HAL Id : hal-01989720 , version 1

Citer

Michel Rigoulet, Xavier M Leverve, Eric Fontaine, Rachid Ouhabi, Bernard Guérin. Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: Dependence upon both fluxes and forces. Molecular and Cellular Biochemistry, 1998, 184 (1-2), pp.35-52. ⟨hal-01989720⟩

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