AMP-Activated Protein Kinase: A Metabolic Stress Sensor in the Heart - Université Grenoble Alpes
Chapitre D'ouvrage Année : 2015

AMP-Activated Protein Kinase: A Metabolic Stress Sensor in the Heart

Résumé

AMP-activated protein kinase (AMPK) is a central cellular signaling hub that senses and responds to different kinds of stress, mainly those triggered by impaired cellular energy homeostasis. Since this is of major importance for the heart, the kinase plays important roles for cardiovascular function in human health and disease. Here, we review recent progress on the molecular structure and role of AMPK and summarize regulation and biological actions of the AMPK pathway, in particular those relevant for the heart. Activation of the kinase is involved in the myocardial response to ischemia, pressure overload, and heart failure. Pharmacological activation of AMPK may prove to be a useful therapeutic strategy in the treatment of these pathologies. (PDF) AMP-Activated Protein Kinase: A Metabolic Stress Sensor in the Heart. Available from: https://www.researchgate.net/publication/283756966_AMP-Activated_Protein_Kinase_A_Metabolic_Stress_Sensor_in_the_Heart [accessed Dec 10 2018].
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Dates et versions

hal-01949687 , version 1 (10-12-2018)

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Citer

Martin Pelosse, Malgorzata Tokarska-Schlattner, Uwe Schlattner. AMP-Activated Protein Kinase: A Metabolic Stress Sensor in the Heart. Springer. Cardiac cytoarchitecture: How to maintain a working heart, Springer International Publishing, pp.187-225, 2015, 978-3-319-15263-9. ⟨10.1007/978-3-319-15263-9_10⟩. ⟨hal-01949687⟩

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