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Chapitre d'ouvrage

AMP-Activated Protein Kinase: A Metabolic Stress Sensor in the Heart

Abstract : AMP-activated protein kinase (AMPK) is a central cellular signaling hub that senses and responds to different kinds of stress, mainly those triggered by impaired cellular energy homeostasis. Since this is of major importance for the heart, the kinase plays important roles for cardiovascular function in human health and disease. Here, we review recent progress on the molecular structure and role of AMPK and summarize regulation and biological actions of the AMPK pathway, in particular those relevant for the heart. Activation of the kinase is involved in the myocardial response to ischemia, pressure overload, and heart failure. Pharmacological activation of AMPK may prove to be a useful therapeutic strategy in the treatment of these pathologies. (PDF) AMP-Activated Protein Kinase: A Metabolic Stress Sensor in the Heart. Available from: https://www.researchgate.net/publication/283756966_AMP-Activated_Protein_Kinase_A_Metabolic_Stress_Sensor_in_the_Heart [accessed Dec 10 2018].
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Chapitre d'ouvrage
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https://hal.univ-grenoble-alpes.fr/hal-01949687
Contributeur : Sarah Hamant <>
Soumis le : lundi 10 décembre 2018 - 12:15:52
Dernière modification le : mercredi 15 juillet 2020 - 09:10:04

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LBFA | UGA

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Martin Pelosse, Malgorzata Tokarska-Schlattner, Uwe Schlattner. AMP-Activated Protein Kinase: A Metabolic Stress Sensor in the Heart. Springer. Cardiac cytoarchitecture: How to maintain a working heart, Springer International Publishing, pp.187-225, 2015, 978-3-319-15263-9. ⟨10.1007/978-3-319-15263-9_10⟩. ⟨hal-01949687⟩

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