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Article Dans Une Revue Frontiers in Nutrition Année : 2022

Assessing Adherence to Healthy Dietary Habits Through the Urinary Food Metabolome: Results From a European Two-Center Study

Pol Castellano-Escuder
  • Fonction : Auteur
Raúl González-Domínguez
  • Fonction : Auteur
Marie-France Vaillant
  • Fonction : Auteur
Patricia Casas-Agustench
  • Fonction : Auteur
Nicole Hidalgo-Liberona
  • Fonction : Auteur
Núria Estanyol-Torres
  • Fonction : Auteur
Thomas Wilson
  • Fonction : Auteur
Manfred Beckmann
  • Fonction : Auteur
Amanda Lloyd
  • Fonction : Auteur
Marion Oberli
  • Fonction : Auteur
Jean-Christian Borel
  • Fonction : Auteur
Marie Joyeux-Faure
  • Fonction : Auteur
Mariette Sicard
  • Fonction : Auteur
Svetlana Artemova
  • Fonction : Auteur
Hugo Terrisse
  • Fonction : Auteur
Paul Dancer
  • Fonction : Auteur
John Draper
  • Fonction : Auteur
Alex Sánchez-Pla
  • Fonction : Auteur
Cristina Andres-Lacueva
  • Fonction : Auteur

Résumé

Background Diet is one of the most important modifiable lifestyle factors in human health and in chronic disease prevention. Thus, accurate dietary assessment is essential for reliably evaluating adherence to healthy habits. Objectives The aim of this study was to identify urinary metabolites that could serve as robust biomarkers of diet quality, as assessed through the Alternative Healthy Eating Index (AHEI-2010). Design We set up two-center samples of 160 healthy volunteers, aged between 25 and 50, living as a couple or family, with repeated urine sampling and dietary assessment at baseline, and 6 and 12 months over a year. Urine samples were subjected to large-scale metabolomics analysis for comprehensive quantitative characterization of the food-related metabolome. Then, lasso regularized regression analysis and limma univariate analysis were applied to identify those metabolites associated with the AHEI-2010, and to investigate the reproducibility of these associations over time. Results Several polyphenol microbial metabolites were found to be positively associated with the AHEI-2010 score; urinary enterolactone glucuronide showed a reproducible association at the three study time points [false discovery rate (FDR): 0.016, 0.014, 0.016]. Furthermore, other associations were found between the AHEI-2010 and various metabolites related to the intake of coffee, red meat and fish, whereas other polyphenol phase II metabolites were associated with higher AHEI-2010 scores at one of the three time points investigated (FDR < 0.05 or β ≠ 0). Conclusion We have demonstrated that urinary metabolites, and particularly microbiota-derived metabolites, could serve as reliable indicators of adherence to healthy dietary habits. Clinical Trail Registration www.ClinicalTrials.gov , Identifier: NCT03169088.

Dates et versions

hal-04554872 , version 1 (22-04-2024)

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Citer

Pol Castellano-Escuder, Raúl González-Domínguez, Marie-France Vaillant, Patricia Casas-Agustench, Nicole Hidalgo-Liberona, et al.. Assessing Adherence to Healthy Dietary Habits Through the Urinary Food Metabolome: Results From a European Two-Center Study. Frontiers in Nutrition, 2022, 9, pp.880770. ⟨10.3389/fnut.2022.880770⟩. ⟨hal-04554872⟩

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