Replacement of missing or diseased hard tissues has become a common procedure in medicine and dentistry. In this field, metallic implants are often coated to improve their biological performance. Herein, the novel electrostatic spray deposition (ESD) technique was employed to fabricate a stacking of bioactive glass (BG) and hydroxyapatite (HAP) deposited onto Ti6Al4V ELI substrates. ESD is an innovative, low-cost method, based on electrohydrodynamics’ laws, that allows the deposition of films with a large variety of original morphologies and phases including crystalline and amorphous ones [1, 2]. In this work, a highly porous coral-like BG coating with an S58 (58 SiO2 – 37 CaO – 5 P2O5 mol. %) formulation was deposited onto a thin and dense HAP layer starting from homogeneous liquid precursor solutions [2, 3]. The constituent phases were selected to combine the high bone-bonding ability of BG with the long-term stability and protection of HAP. Two composites samples (C1 and C2, Fig 1) were fabricated by varying the deposition time of the S58 topcoat to analyze the influence of BG coating thickness on the composite bioactivity i.e. calcium phosphate (CaP) forming ability. In vitro studies were carried out by immersion in simulated body fluid (SBF) solution. Single-layer samples were used as a control. The SBF test revealed that the presence of the BG topcoat layer significantly improves the reactivity, in terms of mineralization response, compared to a single-layer HAP coating. A complete conversion into CaP precipitated layer was produced within 7 days soaking in SBF for both composite samples. Furthermore, the S58 coating thickness was found to influence the bioactivity response. The thinner C1 composite is proposed over the thicker one to promote osteointegration of Ti6Al4V-based implants while maintaining the stability of the device.