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Surface plasmon resonance study of the interaction of N-methyl mesoporphyrin IX with G-quadruplex DNA

Abstract : Surface plasmon resonance (SPR) was used to investigate the interaction between N-methyl mesoporphyrin IX (NMM) and different G-quadruplex (G4) topologies. The study was associated with circular dichroism analysis (CD) to assess the topology of the G4s when they interacted with NMM. We demonstrate the high selectivity of NMM for the parallel G4 structure with a dissociation constant at least ten times lower than those of other G4 topologies. We also confirm the ability of NMM to shift the G4 conformation from both the hybrid and antiparallel topologies toward the parallel structure.
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https://hal.univ-grenoble-alpes.fr/hal-02482405
Contributeur : Jérôme Dejeu <>
Soumis le : mercredi 19 février 2020 - 14:14:35
Dernière modification le : lundi 21 septembre 2020 - 18:34:02
Archivage à long terme le : : mercredi 20 mai 2020 - 12:52:06

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M. Perenon, H. Bonnet, T. Lavergne, J. Dejeu, E. Defrancq. Surface plasmon resonance study of the interaction of N-methyl mesoporphyrin IX with G-quadruplex DNA. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2020, 22, pp.4158-4164. ⟨10.1039/c9cp06321h⟩. ⟨hal-02482405⟩

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