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Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2019

Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands

Résumé

G-triplex nucleic acid structures (G3) have been conjectured to form in vivo but little is known about their physiological functions. The identification of ligands capable of specific binding to G3 structures is therefore highly appealing but remains elusive. Here we report on the assembly of a DNA conjugate which folds into a stable G3 structure. The structural mimic was used to probe the interactions between a G3 ligand and first-in-class G4 ligands, revealing signification binding promiscuity.
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Dates et versions

hal-02481507 , version 1 (19-02-2020)

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Laureen Bonnat, Maelle Dautriche, Taous Saidi, Johana Revol-Cavalier, Jérôme Dejeu, et al.. Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands. Organic & Biomolecular Chemistry, 2019, 17 (38), pp.8726-8736. ⟨10.1039/c9ob01537j⟩. ⟨hal-02481507⟩
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