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Article dans une revue

Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands

Abstract : G-triplex nucleic acid structures (G3) have been conjectured to form in vivo but little is known about their physiological functions. The identification of ligands capable of specific binding to G3 structures is therefore highly appealing but remains elusive. Here we report on the assembly of a DNA conjugate which folds into a stable G3 structure. The structural mimic was used to probe the interactions between a G3 ligand and first-in-class G4 ligands, revealing signification binding promiscuity.
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Article dans une revue
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https://hal.univ-grenoble-alpes.fr/hal-02481507
Contributeur : Jérôme Dejeu <>
Soumis le : mercredi 19 février 2020 - 10:55:18
Dernière modification le : jeudi 6 août 2020 - 04:00:08
Archivage à long terme le : : mercredi 20 mai 2020 - 13:18:06

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Laureen Bonnat, Maelle Dautriche, Taous Saidi, Johana Revol-Cavalier, Jérôme Dejeu, et al.. Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2019, 17 (38), pp.8726-8736. ⟨10.1039/c9ob01537j⟩. ⟨hal-02481507⟩

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