Time-Resolved Serial Femtosecond Crystallography, Towards Molecular Movies of Biomolecules in Action - Université Grenoble Alpes
Chapitre D'ouvrage Année : 2018

Time-Resolved Serial Femtosecond Crystallography, Towards Molecular Movies of Biomolecules in Action

Giorgio Schirò
Martin Weik
  • Fonction : Auteur
  • PersonId : 978699

Résumé

Biological macromolecules, such as proteins, nucleic acids, and complexes thereof, are characterized by specific structural and dynamic features that are the basis of their respective biological activity, and define their dynamic personalities [29]. Understanding macromolecular activity thus requires studying structural changes over time and on various time-scales, such as equilibrium fluctuations and conformational changes orchestrating enzyme catalysis or enabling signal transduction. The first step in human vision, for instance, is the sub-picosecond time-scale photoisomerization of the retinal pigment in rhodopsin [73], which within microseconds leads to the conformational changes required for activation of transducin, the regulatory protein that initiates the signaling cascade beyond the macromolecular level.
Fichier principal
Vignette du fichier
TRSFX_Review_2018_02_23_final_JPC.pdf (2.81 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01993625 , version 1 (26-11-2020)

Identifiants

Citer

Jacques-Philippe Colletier, Giorgio Schirò, Martin Weik. Time-Resolved Serial Femtosecond Crystallography, Towards Molecular Movies of Biomolecules in Action. Petra Fromme; Sebastien Boutet; Mark Hunter. X-ray Free Electron Lasers, Springer International Publishing, pp.331-356, 2018, ⟨10.1007/978-3-030-00551-1_11⟩. ⟨hal-01993625⟩
313 Consultations
327 Téléchargements

Altmetric

Partager

More