The importance of post-translational modifications in systems biology approaches to identify therapeutic targets in cancer metabolism - Université Grenoble Alpes
Article Dans Une Revue Current Opinion in Systems Biology Année : 2017

The importance of post-translational modifications in systems biology approaches to identify therapeutic targets in cancer metabolism

Résumé

Cancer metabolism is reprogrammed to fulfill the needs of proliferation and migration, which is accomplished through different levels of regulation. In recent years, new advances in protein post-translational modifications (PTMs) research have revealed a complex layer of regulatory mechanisms through which PTMs control cell signaling and metabolic pathways, contributing to the diverse metabolic phenotypes found in cancer. Despite the efficacy of current modeling approaches to study cancer metabolism they still lack the capacity to integrate PTMs in their predictions. Here we will review the importance of PTMs in cancer metabolic reprogramming and suggest ways in which computational predictions could be enhanced through the integration of PTMs.
Fichier non déposé

Dates et versions

hal-01989549 , version 1 (22-01-2019)

Identifiants

Citer

Alfonso Martín-Bernabé, Cristina Balcells, Josep Tarragó-Celada, Carles Foguet, Sandrine Bourgoin-Voillard, et al.. The importance of post-translational modifications in systems biology approaches to identify therapeutic targets in cancer metabolism. Current Opinion in Systems Biology, 2017, 3, pp.161-169. ⟨10.1016/j.coisb.2017.05.011⟩. ⟨hal-01989549⟩

Collections

UGA LBFA
40 Consultations
0 Téléchargements

Altmetric

Partager

More