Lésions d’ischémie-reperfusion en transplantation pulmonaire - Université Grenoble Alpes
Article Dans Une Revue La Presse Médicale Année : 2014

Ischemia-reperfusion injury after lung transplantation

Lésions d’ischémie-reperfusion en transplantation pulmonaire

Résumé

Lung ischemia-reperfusion is characterized by diffuse alveolar damage arising from the first hours after transplantation. The first etiology of the primary graft dysfunction in lung is ischemia-reperfusion. It is burdened by an important morbi-mortality. Lung ischemia-reperfusion increases the oxidative stress, inactivates the sodium pump, increases the intracellular calcium, leads to cellular death and the liberation of pro-inflammatory mediators. Researches relative to the reduction of the lung ischemia-reperfusion injuries are numerous but few of them found a place in common clinical practice, because of an insufficient level of proofs. Ex vivolung evaluation is a suitable technique in order to evaluate therapeutics supposed to limit lung ischemia-reperfusion injuries.
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Dates et versions

hal-01969551 , version 1 (04-01-2019)

Identifiants

Citer

Stéphane Gennai, Christophe Pison, Raphael Briot. Lésions d’ischémie-reperfusion en transplantation pulmonaire. La Presse Médicale, 2014, 43 (9), pp.921-930. ⟨10.1016/j.lpm.2014.01.018⟩. ⟨hal-01969551⟩
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