Ischemia-reperfusion injury after lung transplantation
Lésions d’ischémie-reperfusion en transplantation pulmonaire
Résumé
Lung ischemia-reperfusion is characterized by diffuse alveolar damage arising from the first hours after transplantation.
The first etiology of the primary graft dysfunction in lung is ischemia-reperfusion. It is burdened by an important morbi-mortality.
Lung ischemia-reperfusion increases the oxidative stress, inactivates the sodium pump, increases the intracellular calcium, leads to cellular death and the liberation of pro-inflammatory mediators.
Researches relative to the reduction of the lung ischemia-reperfusion injuries are numerous but few of them found a place in common clinical practice, because of an insufficient level of proofs.
Ex vivolung evaluation is a suitable technique in order to evaluate therapeutics supposed to limit lung ischemia-reperfusion injuries.