Metformin overdose: time to move on - Université Grenoble Alpes
Article Dans Une Revue Critical Care Année : 2012

Metformin overdose: time to move on

Résumé

Does metformin-associated lactic acidosis really exist? Despite an old controversy, there is no doubt about it. But do we understand what is going on? Laboratory findings raised several hypotheses explaining the pathophysiology of this disease. The main cause could be an inhibition of either gluconeogenesis or mitochondrial respiratory chain complex I. From bench to bedside, one hypothesis is now confirmed in humans. Metformin poisoning involves, at least partially, a mitochondrial dysfunction.

Dates et versions

hal-01961797 , version 1 (20-12-2018)

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Citer

Jean-Christophe Orban, Eric Fontaine, Carole Ichai. Metformin overdose: time to move on. Critical Care, 2012, 16 (5), pp.164. ⟨10.1186/cc11664⟩. ⟨hal-01961797⟩

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