Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate. - Université Grenoble Alpes Accéder directement au contenu
Article Dans Une Revue Metallomics Année : 2018

Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate.

Résumé

The X-ray structure of an aerated achiral Ru-papain conjugate has revealed the hydroxylation of two tyrosine residues found near the ruthenium ion. The most likely mechanism involves a ruthenium-bound superoxide as the reactive species responsible for the first hydroxylation and the resulting high valent Ru(iv)[double bond, length as m-dash]O species for the second one.
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Dates et versions

hal-01871595 , version 1 (11-09-2018)

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Mickael V Cherrier, Patricia Amara, Barisa Talbi, Michèle Salmain, Juan-Carlos Fontecilla-Camps. Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate.. Metallomics, 2018, 10, pp.1452-1459. ⟨10.1039/c8mt00160j⟩. ⟨hal-01871595⟩
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