Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets - Université Grenoble Alpes Accéder directement au contenu
Article Dans Une Revue Planta Medica Année : 2020

Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets

Mathieu Agostini
  • Fonction : Auteur
Laurence Marcourt
  • Fonction : Auteur
Benjamin Boucherle
  • Fonction : Auteur
Bifeng Gao
  • Fonction : Auteur
Brooks Hybertson
  • Fonction : Auteur
Swapan Bose
  • Fonction : Auteur
Joe Mccord
  • Fonction : Auteur
Annie Millery
  • Fonction : Auteur
Maxime Rome
  • Fonction : Auteur
Emerson Ferreira Queiroz
  • Fonction : Auteur
Jean-Luc Wolfender
Christiane Gallet
  • Fonction : Auteur
Ahcène Boumendjel
  • Fonction : Auteur

Résumé

Abstract Helianthemum nummularium is a European shrub growing at high altitude where it copes with a high level of stress. It was found to be overexpressed in ungulates diets compared to more abundant surrounding plants. These elements combined with the fact that H. nummularium from the Alps has never been investigated prompted us to study the phytochemical composition of its aerial parts. The analysis of the polar extract allowed for the isolation of eight compounds: p-hydroxybenzoic acid, tiliroside, kaempferol, astragalin, quercetin, plantainoside B, quercetin-3-O-glucoside, and quercetin-3-O-glucuronide. We investigated the effect of the polar extract and isolated compounds on nuclear factor erythroid 2-related factor 2 transcription factor, which regulates the expression of a wide variety of cytoprotective genes. We found that the ethanolic extract activates the expression of nuclear factor erythroid 2-related factor 2 in a dose-dependent manner, whereas the pure compounds were much less active. The activation of the nuclear factor erythroid 2-related factor 2 pathway by the plant extract could pave the way for studies to promote healthy aging through protection of cells against oxidative stress. Moreover, the isolated compounds could be investigated alone or in combination in the perspective of making the link between the ungulateʼs preference for this plant and possible use of it for self-medication.
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Dates et versions

hal-04550408 , version 1 (17-04-2024)

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Mathieu Agostini, Isabelle Hininger-Favier, Laurence Marcourt, Benjamin Boucherle, Bifeng Gao, et al.. Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets. Planta Medica, 2020, 86 (16), pp.1185-1190. ⟨10.1055/a-1197-2898⟩. ⟨hal-04550408⟩

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