Hereditary C1 inhibitor deficiency is associated with high spontaneous amidase activity - Université Grenoble Alpes Accéder directement au contenu
Article Dans Une Revue Molecular Immunology Année : 2017

Hereditary C1 inhibitor deficiency is associated with high spontaneous amidase activity

Résumé

function and antigenic C4 level) and contact phase activation (via amidase activity). Bradykinin is respon-sible for angioedema attacks and is produced from contact phase activation secondary to failed C1Inhcontrol.Objective: We aimed to compare the diagnostic performances of spontaneous amidase activity and anti-genic C4 level in C1Inh hereditary angioedema (C1Inh-HAE) patients.Methods: Samples from 185 C1Inh-HAE patients (81 men, 104 women; confirmed by SERPING1 genemutations) and from 99 blood donors (50 men, 49 women) were tested for C1Inh function, antigenic C4level and spontaneous amidase activity.Results: In the C1Inh-HAE group, antigenic C4 level was decreased (n = 135) and amidase activity wasincreased (n = 181). Receiver operating characteristic analyses showed higher diagnostic performancevalues for the spontaneous amidase assay compared to those of antigenic C4.Conclusion: The spontaneous amidase activity assay should replace antigenic C4 level testing and shouldbe tested alongside the C1Inh function for both AE screening and follow up of HAE patients.
Fichier non déposé

Dates et versions

hal-04540454 , version 1 (22-04-2024)

Identifiants

Citer

Delphine Charignon, Arije Ghannam, Denise Ponard, Christian Drouet. Hereditary C1 inhibitor deficiency is associated with high spontaneous amidase activity. Molecular Immunology, 2017, 85, pp.120-122. ⟨10.1016/j.molimm.2017.01.028⟩. ⟨hal-04540454⟩

Collections

UGA CNRS UP-SANTE
1 Consultations
1 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More