Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease - Université Grenoble Alpes
Article Dans Une Revue Memórias do Instituto Oswaldo Cruz Année : 2022

Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease

Résumé

Transforming growth factor beta (TGF-β) is deeply involved on the pathogenesis of Chagas disease. Our group has been investigating the participation of this pleiotropic cytokine in different aspects of Chagas disease over the last 20 years. Important observations have been made, such as: (i) the ability of Trypanosoma cruzi in activating latent TGF-β; (ii) the potential involvement of TGF-β pathway on T. cruzi invasion of host cells; (iii) association of TGF-β with parasite intracellular replication; (iv) cardiac fibrosis development and maintenance; (v) disruption of Connexin-43 plaque structures and (vi) inflammation and immune response. In this perspective article we intend to discuss the advances of the potential use of new therapies targeting TGF-β to treat the cardiac alterations of Chagas disease-affected patients.
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hal-03659057 , version 1 (05-05-2022)

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Mariana Caldas Waghabi, Roberto Rodrigues Ferreira, Rayane da Silva Abreu, Wim Degrave, Elen Mello de Souza, et al.. Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease. Memórias do Instituto Oswaldo Cruz, 2022, 117, pp.e210395. ⟨10.1590/0074-02760210395⟩. ⟨hal-03659057⟩
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