Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function - Archive ouverte HAL Access content directly
Journal Articles Molecular Biology of the Cell Year : 2021

Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function

Abstract

The authors of this study employ budding yeast to model a disease-correlated tubulin mutation to determine how it leads to microtubule dysfunction. They find that the mutation leads to alterations in microtubule dynamics, tubulin isotype usage, and a spindle positioning defect that is due to disrupted microtubule-binding by a dynein regulator.

Dates and versions

hal-03358399 , version 1 (29-09-2021)

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E. Denarier, K. Ecklund, G. Berthier, A. Favier, E O'Toole, et al.. Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function. Molecular Biology of the Cell, 2021, 32 (20), pp.ar10. ⟨10.1091/mbc.E21-05-0237⟩. ⟨hal-03358399⟩
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