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Systematic Analysis of G Protein-Coupled Receptor Gene Expression in Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia Identifies Novel Targets for Pharmacological Control of Adrenal Cushing’s Syndrome

Abstract : Stimulation of cortisol secretion through abnormally expressed G protein-coupled receptors (GPCRs) is a frequent feature of ACTH-independent macronodular adrenal hyperplasia (AIMAH). This has opened a pharmacological strategy that targets GPCRs for the treatment of Cushing's syndrome in AIMAH. However, only few drugs are available for the presently described GPCRs.
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https://hal.univ-grenoble-alpes.fr/hal-02459109
Contributeur : Nadia Cherradi <>
Soumis le : mercredi 29 janvier 2020 - 11:01:37
Dernière modification le : mercredi 19 août 2020 - 11:18:00

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Guillaume Assié, Estelle Louiset, Nathalie Sturm, Fernande René-Corail, Lionel Groussin, et al.. Systematic Analysis of G Protein-Coupled Receptor Gene Expression in Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia Identifies Novel Targets for Pharmacological Control of Adrenal Cushing’s Syndrome. Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2010, 95 (10), pp.E253-E262. ⟨10.1210/jc.2009-2281⟩. ⟨hal-02459109⟩

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