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Article Dans Une Revue Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism Année : 1998

The Acute Regulation of Mineralocorticoid Biosynthesis: Scenarios for the StAR System

Résumé

The zona glomerulosa cell of the adrenal cortex produces mineralocorticoids in response to physiological stimuli (angiotensin II and extracellular K(+)) activating the Ca(2+) messenger system. The mechanisms underlying the generation of the Ca(2+) signal have been analyzed extensively and recent developments have contributed to bridging the gap between intracellular signals and activation of the biological function. This article summarizes the current knowledge on the intracellular targets of the Ca(2+) messenger, obtained mainly in bovine glomerulosa cells. Ca(2+) appears to exert a dual effect, both at the intramitochondrial level and at the nuclear level, where it activates steroidogenic acute regulatory protein (StAR) gene transcription.

Dates et versions

hal-02459068 , version 1 (29-01-2020)

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Citer

Nadia Cherradi, Alessandro Capponi. The Acute Regulation of Mineralocorticoid Biosynthesis: Scenarios for the StAR System. Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism , 1998, 9 (10), pp.412-418. ⟨10.1016/s1043-2760(98)00099-x⟩. ⟨hal-02459068⟩

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