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The structure of the nucleoprotein of Influenza D shows that all Orthomyxoviridae nucleoproteins have a similar NPCORE, with or without a NPTAIL for nuclear transport

Abstract : This paper focuses on the nucleoprotein (NP) of the newly identified member of the Orthomyxoviridae family, Influenza D virus. To date several X-ray structures of NP of Influenza A (A/NP) and B (B/NP) viruses and of infectious salmon anemia (ISA/NP) virus have been solved. Here we purified, characterized and solved the X-ray structure of the tetrameric D/NP at 2.4 Å resolution. The crystal structure of its core is similar to NP of other Influenza viruses. However, unlike A/NP and B/NP which possess a flexible amino-terminal tail containing nuclear localization signals (NLS) for their nuclear import, D/NP possesses a carboxy-terminal tail (D/NPTAIL). We show that D/NPTAIL harbors a bipartite NLS and designed C-terminal truncated mutants to demonstrate the role of D/NPTAIL for nuclear transport.
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https://hal.univ-grenoble-alpes.fr/hal-01997471
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Soumis le : jeudi 24 septembre 2020 - 09:14:43
Dernière modification le : samedi 26 septembre 2020 - 03:08:46

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Amélie Donchet, Justine Oliva, Alice Labaronne, Laura Tengo, Myriam Miloudi, et al.. The structure of the nucleoprotein of Influenza D shows that all Orthomyxoviridae nucleoproteins have a similar NPCORE, with or without a NPTAIL for nuclear transport. Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.600. ⟨10.1038/s41598-018-37306-y⟩. ⟨hal-01997471⟩

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