Neutron scattering in the biological sciences: progress and prospects
Rana Ashkar
,
Hassina Bilheux
,
Heliosa Bordallo
,
Robert Briber
,
David Callaway
,
Xiaolin Cheng
(1)
,
Xiang Qiang Chu
,
Joseph Curtis
,
Mark Dadmun
(2)
,
Paul Fenimore
,
David Fushman
(3)
,
Frank Gabel
(4)
,
Kushol Gupta
,
Frederick Herberle
,
Frank Heinrich
,
Liang Hong
,
John Katsaras
,
Zvi Kelman
,
Eugenia Kharlampieva
,
Flora Kneller
,
Andrey Kovalevsky
,
Susan Krueger
(5)
,
Paul Langan
(6)
,
Raquel Lieberman
,
Yun Liu
(7)
,
Mathias Losche
,
Edward Lyman
,
Yimin Mao
,
John Marino
,
Carla Mattos
,
Flora Meilleur
,
Peter Moody
(8)
,
Jonathan Nickels
,
William O'Dell
,
Hugh O'Neill
(9)
,
Ursula Perez-Salas
,
Judith Peters
(4)
,
Loukas Petridis
,
Alexei Sokolov
(10)
,
Christopher Stanley
,
Norman Wagner
,
Michael Weinrich
,
Kevin Weiss
,
Troy Wymore
,
Yang Zhang
,
Jeremy Smith
,
Xiang-Qiang Chu
,
Gérald Kneller
(11)
,
Peter Peters
1
RITM -
Réseaux Innovation Territoires et Mondialisation
2 Dept Chem, UnivTennessee
3 Ctr Biomol Struct & Org
4 IBS - UMR 5075 - Institut de biologie structurale
5 Ctr Neutron Res
6 LANL - Theorical Division
7 Polytechnic School - Computer Engineering Department
8 Department of Chemistry [Leicester]
9 ANU - Australian National University
10 University of Tennessee System
11 CBM - Centre de biophysique moléculaire
2 Dept Chem, UnivTennessee
3 Ctr Biomol Struct & Org
4 IBS - UMR 5075 - Institut de biologie structurale
5 Ctr Neutron Res
6 LANL - Theorical Division
7 Polytechnic School - Computer Engineering Department
8 Department of Chemistry [Leicester]
9 ANU - Australian National University
10 University of Tennessee System
11 CBM - Centre de biophysique moléculaire
Rana Ashkar
- Function : Author
Hassina Bilheux
- Function : Author
Heliosa Bordallo
- Function : Author
Robert Briber
- Function : Author
David Callaway
- Function : Author
Xiang Qiang Chu
- Function : Author
Joseph Curtis
- Function : Author
Paul Fenimore
- Function : Author
Kushol Gupta
- Function : Author
Frederick Herberle
- Function : Author
Frank Heinrich
- Function : Author
Liang Hong
- Function : Author
John Katsaras
- Function : Author
Zvi Kelman
- Function : Author
Eugenia Kharlampieva
- Function : Author
Flora Kneller
- Function : Author
Andrey Kovalevsky
- Function : Author
Raquel Lieberman
- Function : Author
Mathias Losche
- Function : Author
Edward Lyman
- Function : Author
Yimin Mao
- Function : Author
John Marino
- Function : Author
Carla Mattos
- Function : Author
Flora Meilleur
- Function : Author
Jonathan Nickels
- Function : Author
William O'Dell
- Function : Author
Ursula Perez-Salas
- Function : Author
Judith Peters
- Function : Author
- PersonId : 1042271
- IdHAL : judith-peters
- ORCID : 0000-0001-5151-7710
- IdRef : 158803663
Loukas Petridis
- Function : Author
Christopher Stanley
- Function : Author
Norman Wagner
- Function : Author
Michael Weinrich
- Function : Author
Kevin Weiss
- Function : Author
Troy Wymore
- Function : Author
Yang Zhang
- Function : Author
- PersonId : 757354
- ORCID : 0000-0003-4102-2671
Jeremy Smith
- Function : Author
Xiang-Qiang Chu
- Function : Author
Gérald Kneller
- Function : Author
- PersonId : 175857
- IdHAL : gerald-kneller
- ORCID : 0000-0002-3374-3797
- IdRef : 089819993
Peter Peters
- Function : Author
Abstract
The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.