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Article dans une revue

Health-Related Quality of Life in Patients with Alpha-1 Antitrypsin Deficiency: The French Experience

Abstract : The French registry of patients with alpha-1 antitrypsin deficiency (AATD)-associated emphysema was launched in 2006. Here, we aimed to report on the baseline characteristics of these patients, their health-related quality of life (HRQoL) and factors associated with HRQoL. Another goal was to survey the practices of French physicians regarding augmentation therapy. We included 273 patients with AATD, emphysema, obstructive-pattern [forced expiratory volume in 1 sec/forced volume capacity (FEV1/FVC) < 0.7], FEV1 ≤ 80% predicted. Mean (SD) age was 51.8 (11.1) years, 240 (87.9%) of patients were smokers or ex-smokers, mean (SD) FEV1 was 40.5% (15.7) predicted. Mean (SD) SGRQ score was 49.0 (20.0) and was higher for females than males (52.7 [20.7] vs 46.8 [18.2]; p = 0.01). Dyspnea showed the strongest association with SGRQ score (r = 0.65; p < 0.0001), followed by chronic bronchitis (r = 0.33; p < 0.0001) and wheezing (r = 0.32; p < 0.0001). Number of exacerbations in the year before inclusion was also significantly associated with SGRQ score (r = 0.36; p < 0.0001). The SGRQ score was associated with the 6-min walking distance (r = -0.53, p < 0.0001), FEV1 (% predicted, r = -0.53, p < 0.0001) and DLCO (% predicted, r = -0.52, p < 0.0001). It was also associated with the GOLD 2006 (r = 0.53; p < 0.0001) and GOLD 2011 (r = 0.63; p< 0.0001) classifications and with the BODE index (r = 0.37; p < 0.0001). Age, history of tobacco smoking or current smoking did not show any association with SGRQ total scores. On multivariate analysis, a model including age, chronic bronchitis, dyspnea (MRC scale), diffusing lung capacity and 6-min walking distance explained 57% of the variation in the score. The French registry provides important insights into the clinical characteristics of French patients with AATD-related emphysema. TRIAL REGISTRATION: ClinicalTrials.gov NCT00700934.
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https://hal.univ-grenoble-alpes.fr/hal-01969364
Contributeur : Sarah Hamant <>
Soumis le : vendredi 4 janvier 2019 - 09:18:28
Dernière modification le : vendredi 18 septembre 2020 - 14:34:41

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Clément Gauvain, Jean-Francois Mornex, Christophe Pison, Antoine Cuvelier, Malika Balduyck, et al.. Health-Related Quality of Life in Patients with Alpha-1 Antitrypsin Deficiency: The French Experience. COPD: Journal of Chronic Obstructive Pulmonary Disease, Taylor & Francis, 2015, 12 (sup1), pp.46-51. ⟨10.3109/15412555.2015.1022645⟩. ⟨hal-01969364⟩

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