Accéder directement au contenu Accéder directement à la navigation
Chapitre d'ouvrage

l-Arginine and TNFα Production in Macrophages: A Focus on Metabolism, Aging, Metabolic Syndrome, and Type 2 Diabetes

Abstract : Arginine (Arg) has long been known to be a major regulator of immunity via its metabolic and physiological functions. In the 1950s, it was classified as a non-essential amino acid by Rose since Arg could be synthesized at the whole body level, mainly in the kidneys, after the conversion of intestinal citrulline (Cit) via argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL). But things changed when Barbul et al. (Surg Forum 28:101–103, 1977) observed, surprisingly, that Arg was an immunomodulator via a thymic effect. At the same time, they observed that Arg could be essential in several situations, like growth or sepsis. Finally in the 1990s, Albina et al. (J Immunol 147:144–148, 1991) demonstrated that macrophages were able to produce nitric oxide (NO). These pioneering observations opened a new field of research focused on the regulation of macrophage functions by Arg.
Type de document :
Chapitre d'ouvrage
Liste complète des métadonnées

https://hal.univ-grenoble-alpes.fr/hal-01957509
Contributeur : Sarah Hamant <>
Soumis le : lundi 17 décembre 2018 - 13:46:14
Dernière modification le : mardi 28 juillet 2020 - 03:02:25

Identifiants

Collections

Citation

Charlotte Breuillard, Christophe Moinard, Marie-Chantal Farges. l-Arginine and TNFα Production in Macrophages: A Focus on Metabolism, Aging, Metabolic Syndrome, and Type 2 Diabetes. Humana Press, Cham. L-Arginine in Clinical Nutrition, Springer Nature Switzerland AG., pp.131-144, 2016, 978-3-319-26007-5. ⟨10.1007/978-3-319-26009-9_11⟩. ⟨hal-01957509⟩

Partager

Métriques

Consultations de la notice

352