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Article dans une revue

Vitamin D Status and Indices of Bone Turnover in Older European Adults

Abstract : An increased rate of bone turnover increases risk of osteoporotic fracture later in life. The concentration of 25-hydroxyvitamin D that contributes to an elevated rate of bone turnover in older adults is unclear. The objective of this study was to investigate the associations between 25-hydroxyvitamin D and biochemical markers of bone turnover in an older, pan-European cohort. 25-hydroxyvitamin D and serum markers of bone-formation (osteocalcin and bone-specific alkaline phosphatase) were assessed by ELISA, while urinary markers of bone-resorption (pyridinoline and deoxypyridinoline) were assessed by HPLC. Six percent, 36%, and 64% of subjects had 25-hydroxyvitamin D concentrations <25, <50, and <80 nmol/L throughout the year, respectively. 25-hydroxyvitamin D was significantly and inversely correlated with serum bone-specific alkaline phosphatase (r = 0.119; p = 0.022) and urinary pyridinoline (r = 0.207; p < 0.0001) and deoxypyridinoline (r = 0.230; p < 0.0001). Stratification on the basis of tertiles [T] of 25-hydroxyvitamin D (< 47.6 [T-1]; 47.6-85.8 [T-2]; >85.8 [T-3] nmol/L), showed that urinary pyridinoline and deoxypyridinoline were significantly lower in subjects in the 2nd and 3rd compared to the 1st tertile (p < 0.015). Low vitamin D status (<50 nmol/L) was associated with an increased rate of bone turnover in this older pan-European cohort.
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https://hal.univ-grenoble-alpes.fr/hal-01932854
Contributeur : Sarah Hamant <>
Soumis le : vendredi 23 novembre 2018 - 13:40:29
Dernière modification le : mercredi 15 juillet 2020 - 09:10:04

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Kelly Seamans, Tom Hill, Lisa Scully, Nathalie Meunier, Maude Andrillo-Sanchez, et al.. Vitamin D Status and Indices of Bone Turnover in Older European Adults. International Journal for Vitamin and Nutrition Research, Hogrefe, 2011, 81 (5), pp.277 - 285. ⟨10.1024/0300-9831/a000075⟩. ⟨hal-01932854⟩

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