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Structure of the C-Terminal Domain of Lettuce Necrotic Yellows Virus Phosphoprotein

Abstract : Lettuce necrotic yellows virus (LNYV) is a prototype of the plant-adapted cytorhabdoviruses. Through a meta-prediction of disorder, we localized a folded C-terminal domain in the amino acid sequence of its phosphoprotein. This domain consists of an autonomous folding unit that is monomeric in solution. Its structure, solved by X-ray crystallography, reveals a lollipop-shaped structure comprising five helices. The structure is different from that of the corresponding domains of other Rhabdoviridae, Filoviridae, and Paramyxovirinae; only the overall topology of the polypeptide chain seems to be conserved, suggesting that this domain evolved under weak selective pressure and varied in size by the acquisition or loss of functional modules.
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Contributeur : Frank Thomas <>
Soumis le : lundi 18 décembre 2017 - 10:09:13
Dernière modification le : jeudi 11 janvier 2018 - 06:26:04

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Nicolas Martinez, Euripedes A Ribeiro, Cedric Leyrat, Nicolas Tarbouriech, Rob W H Ruigrok, et al.. Structure of the C-Terminal Domain of Lettuce Necrotic Yellows Virus Phosphoprotein. Journal of Virology, American Society for Microbiology, 2013, 87 (17), pp.9569 - 9578. ⟨10.1128/JVI.00999-13⟩. ⟨hal-01666112⟩



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