Trinucleotide repeat expansion Acetylcholinesterase deficiency Heart failure Humans CTG repeats Astrocytes RNA splicing In vivo Gene editing PacBio BIOLOGIE MOLECULAIRE Lc3 Mice CRISPR/Cas9 Myotonic dystrophy Alternative splicing ARN RNA interference Thérapie génique MBNL Myelin Myotonic Dystrophy Type 1 Glucocorticoids Glutamate Mouse models Neuron Exercise Acute coronary syndrome Cell penetrating peptide Quantitative microdialysis GABA Male Intermediate filament Cell culture model Myotonic dystrophy mouse models DM1 Muscular dystrophy Heart Expression Brain Transcriptomics Motoneuron GSK3␤ CONGENITAL MYATHENIC SYNDROME Transgenic mouse Glucocorticoid-receptor Myotonic Dystrophy Dystrophin Diaphragm Myostatin Duchenne muscular dystrophy Cardiac muscle KNOCKOUT MICE Muscle CTG repeat contractions CMS Fibrosis Centronuclear myopathy Exercice DMPK Dilated cardiomyopathy Transgenic mouse model Brain dysfunction CTG repeat instability Dystrophie Myotonique Antisense oligonucleotides ACETYLCHOLINESTERASE Desmin CRISPRi AAV Acetylcholinesterase knockout mouse Skeletal muscle Myotonic Dystrophy type 1 Gene therapy DMSXL mice Oligodendrocytes Gene Therapy Trinucleotide Repeat Expansion Oligodendrocyte Hypoxia Long read sequencing Cell model Therapy Knockout RNA biology Aging PCR Mouse model Central nervous system Animals Dynamin 2 Myotonic dystrophy type 1 Astrocyte Autophagy Glial cells Cytoskeleton Antisense oligonucleotide Genotype phenotype correlation Dystrophie myotonique Maximal force