In this paper, a new multiscale macro-element formulation for the steel–concrete interface modeling is proposed. This element allows for the representation of the behavior of steel and the interface zone surrounding it. It can also model the interfacial bond stresses in between. Compared to conventional interface models of the literature, which employ separate mesh elements for the steel and the interface, utilizing a macro-element to model both components simplifies the creation of a reinforced concrete structure mesh. Moreover, the macro-element equilibrium is solved using a sub-structuring method that aims to reduce the computational cost. At the global level, it is considered as a four-node element linked to two-dimensional and three-dimensional concrete elements. At the local level, an assembly of multiple three-node bar elements with bond stresses is performed. An inner mesh discretization is therefore possible at the local level independently of the global level. The coupling between the two modeling scales is done using a static condensation technique. The formulation of the macro-element is presented in this paper. A selection of numerical examples is provided. The presented applications demonstrate the robustness of the proposed interface model and its capacity to reproduce the experimental behavior of reinforced concrete structural elements.