Effect of a lifestyle intervention to prevent weight gain at initiation of insulin pump therapy in type 2 diabetes: A randomized, controlled, multicentre trial - Université Grenoble Alpes Accéder directement au contenu
Article Dans Une Revue Diabetes Research and Clinical Practice Année : 2023

Effect of a lifestyle intervention to prevent weight gain at initiation of insulin pump therapy in type 2 diabetes: A randomized, controlled, multicentre trial

Martin Carvalho
  • Fonction : Auteur
Hafid Amougay
  • Fonction : Auteur
Hélène Du-Boullay
  • Fonction : Auteur
Alexandra Crand
  • Fonction : Auteur
Chloé Lamy
  • Fonction : Auteur
Laura Borges
  • Fonction : Auteur
Sandy Gorain
  • Fonction : Auteur
Jean-Christian Borel
  • Fonction : Auteur
Anne-Laure Borel

Résumé

Insulin pump therapy improves glycaemic control in individuals with type 2 diabetes. However, it may be associated with weight gain. Aim: To test the effectiveness of a six-month dietary and physical activity intervention, compared to usual care, on weight gain prevention after initiation of insulin pump. Methods: Multicentre randomized, controlled trial of 54 individuals. Primary endpoint was between group difference in weight gain at six-months. Results: Weight gain after 6 months of insulin pump treatment did not differ between groups: mean 3.2 (3.9) kg in the control group and 3.9 (3.8) kg in the intervention group, (p = 0.56). HbA1c improved without difference between groups. Post-hoc multivariate analysis of all participants found that weight gain was independently associated with younger age, active smoking, and the magnitude of HbA1c reduction. A 1 % decrease in HbA1c was associated with an increase of 0.94 kg [95 % Confidence Interval 0.47; 1.41], p < 0.001. Conclusions: Treatment intensification by insulin pump therapy in patients with type 2 diabetes is effective to improve glycaemic control. A gain of about 1 kg per 1 % drop in HbA1c can be expected after insulin treatment intensification. This weight gain was not prevented by a home-base, individualized, 6-months lifestyle intervention program.
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Dates et versions

hal-04560350 , version 1 (26-04-2024)

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Citer

Cécile Bétry, Sandrine Lablanche, Martin Carvalho, Hafid Amougay, Hélène Du-Boullay, et al.. Effect of a lifestyle intervention to prevent weight gain at initiation of insulin pump therapy in type 2 diabetes: A randomized, controlled, multicentre trial. Diabetes Research and Clinical Practice, 2023, 200, pp.110698. ⟨10.1016/j.diabres.2023.110698⟩. ⟨hal-04560350⟩
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