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Article Dans Une Revue Biomechanics and Modeling in Mechanobiology Année : 2024

Mechanical experimentation of the gastrointestinal tract: a systematic review

Résumé

The gastrointestinal (GI) organs of the human body are responsible for transporting and extracting nutrients from food and drink, as well as excreting solid waste. Biomechanical experimentation of the GI organs provides insight into the mechanisms involved in their normal physiological functions, as well as understanding of how diseases can cause disruption to these. Additionally, experimental findings form the basis of all finite element (FE) modelling of these organs, which have a wide array of applications within medicine and engineering. This systematic review summarises the experimental studies that are currently in literature (n=247) and outlines the areas in which experimentation is lacking, highlighting what is still required in order to more fully understand the mechanical behaviour of the GI organs. These include i) more human data, allowing for more accurate modelling for applications within medicine, ii) an increase in time-dependent studies, and iii) more sophisticated in vivo testing methods which allow for both the layerand direction-dependent characterisation of the GI organs. The findings of this review can also be used to identify experimental data for the readers' own constitutive or FE modelling as the experimental studies have been grouped in terms of organ (oesophagus, stomach, small intestine, large intestine or rectum), test condition (ex vivo or in vivo), number of directions studied (isotropic or anisotropic), species family (human, porcine, feline etc.), tissue condition (intact wall or layer-dependent) and the type of test performed (biaxial tension, inflation-extension, distension (pressure-diameter), etc.). Furthermore, the studies which investigated the time-dependent (viscoelastic) behaviour of the tissues have been presented.
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Dates et versions

hal-04231178 , version 1 (06-10-2023)

Identifiants

Citer

Ciara Durcan, Mokarram Hossain, Grégory Chagnon, Djordje Perić, Edouard Girard. Mechanical experimentation of the gastrointestinal tract: a systematic review. Biomechanics and Modeling in Mechanobiology, 2024, 23, pp.23-59. ⟨10.1007/s10237-023-01773-8⟩. ⟨hal-04231178⟩
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