Accéder directement au contenu Accéder directement à la navigation
Nouvelle interface
Article dans une revue

Socialization of Providencia stuartii Enables Resistance to Environmental Insults

Abstract : Providencia stuartii is a highly social pathogen responsible for nosocomial chronic urinary tract infections. The bacterium indeed forms floating communities of cells (FCC) besides and prior-to canonical surface-attached biofilms (SAB). Within P. stuartii FCC, cells are riveted one to another owing to by self-interactions between its porins, viz. Omp-Pst1 and Omp-Pst2. In pathophysiological conditions, P. stuartii is principally exposed to high concentrations of urea, ammonia, bicarbonate, creatinine and to large variations of pH, questioning how these environmental cues affect socialization, and whether formation of SAB and FCC protects cells against those. Results from our investigations indicate that FCC and SAB can both form in the urinary tract, endowing cells with increased resistance and fitness. They additionally show that while Omp-Pst1 is the main gateway allowing penetration of urea, bicarbonate and ammonia into the periplasm, expression of Omp-Pst2 enables resistance to them.
Liste complète des métadonnées
Contributeur : Jacques-Philippe Colletier Connectez-vous pour contacter le contributeur
Soumis le : jeudi 24 novembre 2022 - 08:47:01
Dernière modification le : vendredi 25 novembre 2022 - 04:11:00


microorganisms-10-00901-v3.pdf icone licence fichier
Fichiers éditeurs autorisés sur une archive ouverte




Julie Lopes, Guillaume Tetreau, Kevin Pounot, Mariam El Khatib, Jacques-Philippe Colletier. Socialization of Providencia stuartii Enables Resistance to Environmental Insults. Microorganisms, 2022, 10 (5), pp.901. ⟨10.3390/microorganisms10050901⟩. ⟨hal-03847651⟩



Consultations de la notice


Téléchargements de fichiers