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Article dans une revue

Unravelling the Adaptation Mechanisms to High Pressure in Proteins

Abstract : Life is thought to have appeared in the depth of the sea under high hydrostatic pressure. Nowadays, it is known that the deep biosphere hosts a myriad of life forms thriving under high-pressure conditions. However, the evolutionary mechanisms leading to their adaptation are still not known. Here, we show the molecular bases of these mechanisms through a joint structural and dynamical study of two orthologous proteins. We observed that pressure adaptation involves the decoupling of protein–water dynamics and the elimination of cavities in the protein core. This is achieved by rearranging the charged residues on the protein surface and using bulkier hydrophobic residues in the core. These findings will be the starting point in the search for a complete genomic model explaining high-pressure adaptation.
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Soumis le : mercredi 3 août 2022 - 12:58:29
Dernière modification le : vendredi 5 août 2022 - 14:44:08


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Antonino Caliò, Cécile Dubois, Stéphane Fontanay, Michael Marek Koza, François Hoh, et al.. Unravelling the Adaptation Mechanisms to High Pressure in Proteins. International Journal of Molecular Sciences, MDPI, 2022, 23 (15), pp.8469. ⟨10.3390/ijms23158469⟩. ⟨hal-03744880⟩



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