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Survival of patients with chronic respiratory failure on long-term oxygen therapy and or non-invasive ventilation at home

Abstract : BACKGROUND & AIMS: Chronic respiratory failure (CRF) is the common fate of respiratory diseases where systemic effects contribute to outcomes. In a prospective cohort of home-treated patients with CRF, we looked for predictors of long-term survival including respiratory, nutritional and inflammatory dimensions. METHODS: 637 stable outpatients with CRF, 397 men, 68 ± 11 years, on long-term oxygen therapy and/or non-invasive ventilation from 21 chest clinics were enrolled and followed over 53 ± 31 months. CRF resulted from Chronic Obstructive Pulmonary Disease (COPD) in 48.5%, restrictive disorders 32%, mixed (obstructive and restrictive patterns) respiratory failure 13.5%, bronchiectasis 6%. Demographic characteristics, smoking habits, underlying respiratory diseases, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), arterial blood gases, 6-min walking distance (6MWD), hemoglobin, body mass index (BMI), serum albumin, transthyretin, C-reactive protein (CRP), history of respiratory assistance, antibiotic and oral corticosteroid use during the previous year were recorded.
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https://hal.univ-grenoble-alpes.fr/hal-01969395
Contributeur : Sarah Hamant <>
Soumis le : vendredi 4 janvier 2019 - 09:52:33
Dernière modification le : dimanche 25 octobre 2020 - 07:04:25

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Noël Cano, Claude Pichard, Isabelle Court-Fortune, Frédéric Costes, Luc Cynober, et al.. Survival of patients with chronic respiratory failure on long-term oxygen therapy and or non-invasive ventilation at home. Clinical Nutrition, Elsevier, 2015, 34 (4), pp.739-744. ⟨10.1016/j.clnu.2014.08.011⟩. ⟨hal-01969395⟩

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