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Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study

Abstract : Omalizumab is a monoclonal anti-IgE antibody used to treat severe allergic asthma (SAA). The aim of the STELLAIR study was to determine the importance of pre-treatment blood eosinophil count as a predictive measure for response to omalizumab.This retrospective real-life study was conducted in France between December 2015 and September 2016 using medical records of SAA omalizumab-treated patients. Response to omalizumab was assessed by three criteria: physician evaluation, reduction of ≥40% in annual exacerbation rate and a combination of both. Response rate was calculated according to blood eosinophil count measured in the year prior to omalizumab initiation.872 SAA omalizumab-treated patients were included by 78 physicians (723 adults (age ≥18 years) and 149 minors (age 6-17 years)). Blood eosinophil count was ≥300 cells·µL-1 in 52.1% of adults and 73.8% of minors. By physician evaluation, 67.2% of adults and 77.2% of minors were responders and 71.1% adults and 78.5% minors had a ≥40% reduction in the exacerbation rate. In adults, the response rate for combined criteria was 58.4% (95% CI 53.2-63.4%) for blood eosinophils ≥300 cells·µL-1 (n=377) and 58.1% (95% CI 52.7-63.4%) for blood eosinophils <300 cells·µL-1 (n=346).This study shows that a large proportion of patients with SAA have a blood eosinophil count ≥300 cells·µL-1, and suggests that omalizumab effectiveness is similar in "high" and "low" eosinophil subgroups.
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https://hal.univ-grenoble-alpes.fr/hal-01962427
Contributeur : Sarah Hamant <>
Soumis le : jeudi 20 décembre 2018 - 15:49:18
Dernière modification le : mercredi 9 septembre 2020 - 03:13:05

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Marc Humbert, Camille Taille, Laurence Mala, Vincent Le Gros, Jocelyne Just, et al.. Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study. European Respiratory Journal, European Respiratory Society, 2018, 51 (5), pp.1702523. ⟨10.1183/13993003.02523-2017⟩. ⟨hal-01962427⟩

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