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Article dans une revue

Hyperosmolar sodium-lactate in the ICU: vascular filling and cellular feeding

Abstract : Hyperosmolar lactate-based solutions have been used for fluid resuscitation in ICU patients. The positive effects observed with these fluids have been attributed to both lactate metabolism and the hypertonic nature of the solutions. In a recent issue of Critical Care, Duburcq and colleagues studied three types of fluid infused at the same volume in a porcine model of endotoxic shock. The control group was resuscitated with 0.9% NaCl, and the two other groups received either hypertonic sodium-lactate or hypertonic sodium-bicarbonate. The two hypertonic fluids proved to be more effective than 0.9% NaCl for resuscitation in this model. However, some parameters were more effectively corrected by hypertonic sodium-lactate than by hypertonic sodium-bicarbonate, suggesting that lactate metabolism was beneficial in these cases.
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Contributeur : Sarah Hamant <>
Soumis le : jeudi 20 décembre 2018 - 10:52:12
Dernière modification le : mercredi 15 juillet 2020 - 09:10:04

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Eric Fontaine, Jean-Christophe Orban, Carole Ichai. Hyperosmolar sodium-lactate in the ICU: vascular filling and cellular feeding. Critical Care, BioMed Central, 2014, 18 (6), ⟨10.1186/s13054-014-0599-5⟩. ⟨hal-01961759⟩



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