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Communication dans un congrès

Producing a set of models for the iron homeostasis network

Abstract : This paper presents a method for modeling biological systems which combines formal techniques on intervals, numerical simulations and satisfaction of Signal Temporal Logic (STL) formulas. The main modeling challenge addressed by this approach is the large uncertainty in the values of the parameters due to the experimental difficulties of getting accurate biological data. This method considers intervals for each parameter and a formal description of the expected behavior of the model. In a first step, it produces reduced intervals of possible parameter values. Then by performing a systematic search in these intervals, it defines sets of parameter values used in the next step. This procedure aims at finding a sub-space where the model robustly behaves as expected. We apply this method to the modeling of the cellular iron homeostasis network in erythroid progenitors. The produced model describes explicitly the regulation mechanism which acts at the translational level.
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Communication dans un congrès
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https://hal.univ-grenoble-alpes.fr/hal-01936055
Contributeur : Sarah Hamant <>
Soumis le : mardi 27 novembre 2018 - 11:24:58
Dernière modification le : vendredi 17 juillet 2020 - 14:06:15

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Nicolas Mobilia, Alexandre Donzé, Jean-Marc Moulis, Eric Fanchon. Producing a set of models for the iron homeostasis network. Proceedings Second International Workshop on Hybrid Systems and Biology (HBS 2013), Thao Dang and Carla Piazza, Sep 2013, Taormina, Italy. pp.92-98, ⟨10.4204/EPTCS.125.7⟩. ⟨hal-01936055⟩

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