Rye polyphenols and the metabolism of n-3 fatty acids in rats: a dose dependent fatty fish-like effect - Université Grenoble Alpes
Article Dans Une Revue Scientific Reports Année : 2017

Rye polyphenols and the metabolism of n-3 fatty acids in rats: a dose dependent fatty fish-like effect

Résumé

As long-chain fatty acids (LCFA) of the n-3 series are critically important for human health, fish consumption has considerably increased in recent decades, resulting in overfishing to respond to the worldwide demand, to an extent that is not sustainable for consumers' health, fisheries economy, and marine ecology. In a recent study, it has been shown that whole rye (WR) consumption improves blood and liver n-3 LCFA levels and gut microbiota composition in rats compared to refined rye. The present work demonstrates that specific colonic polyphenol metabolites may dose dependently stimulate the synthesis of n-3 LCFA, possibly through their microbial and hepatic metabolites in rats. The intake of plant n-3 alpha-linolenic acid and WR results in a sort of fatty fish-like effect, demonstrating that the n-3 LCFA levels in blood and tissues could be increased without eating marine foods, and therefore without promoting unsustainable overfishing, and without damaging marine ecology.
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Dates et versions

hal-01928613 , version 1 (17-07-2019)

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Fayçal Ounnas, Michel de Lorgeril, Patricia Salen, François Laporte, Luca Calani, et al.. Rye polyphenols and the metabolism of n-3 fatty acids in rats: a dose dependent fatty fish-like effect. Scientific Reports, 2017, 7 (1), ⟨10.1038/srep40162⟩. ⟨hal-01928613⟩
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