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Article Dans Une Revue Glycoconjugate Journal Année : 2017

The "in and out" of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate.

Résumé

The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their ability to bind and modulate a multitude of protein ligands. These interactions involve internal oligosaccharide sequences defined by their sulfation patterns. Amongst these, the 6-O-sulfation of HS contributes significantly to the polysaccharide structural diversity and is critically involved in the binding of many proteins. HS 6-O-sulfation is catalyzed by 6-O-sulfotransferases (6OSTs) during biosynthesis, and it is further modified by the post-synthetic action of 6-O-endosulfatases (Sulfs), two enzyme families that remain poorly characterized. The aim of the present review is to summarize the contribution of 6-O-sulfates in HS structure/function relationships and to discuss the present knowledge on the complex mechanisms regulating HS 6-O-sulfation.
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Dates et versions

hal-01461493 , version 1 (08-02-2017)

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Citer

Rana El Masri, Amal Seffouh, Hugues Lortat-Jacob, Romain R Vivès. The "in and out" of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate.. Glycoconjugate Journal, 2017, 34 (3), pp.285-298. ⟨10.1007/s10719-016-9736-5⟩. ⟨hal-01461493⟩
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