A model of apoptosis receptor reactions to study cell fate decision
Résumé
The apoptotic signaling pathway designates a set of biochemical reactions involved in programmed cell death. One of the triggering mechanisms of apoptosis is the binding of death ligands to death receptors on the cell membrane, a known stimulus for the activation of the so-called extrinsic apoptosis signaling pathway. Stimulation by death ligands results in an important variability in cell response dynamics that elicits differing fates: cell survival or cell death. To understand the hallmarks of this cell fate decision and the heterogeneity of cell response, a system of ordinary differential equations based on mass-action rate laws was implemented to represent the reactions at the receptor level and evaluate the cell dynamics in response to anticancer drugs.
Domaines
Sciences du Vivant [q-bio] Biologie cellulaire Cancer Ingénierie biomédicale Pharmacologie Systèmes dynamiques [math.DS] Intelligence artificielle [cs.AI] Bio-informatique [q-bio.QM] Biotechnologie Apprentissage [cs.LG] Modélisation et simulation Traitement des images [eess.IV] Traitement du signal et de l'image [eess.SP] Bio-Informatique, Biologie Systémique [q-bio.QM] Biochimie, Biologie Moléculaire
Origine : Fichiers produits par l'(les) auteur(s)