Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction - Groupe Réponse immunitaire aux pathogènes et au soi altéré / Immune Response to Pathogens and altered-self Group (IBS-IRPAS) Accéder directement au contenu
Article Dans Une Revue Viruses Année : 2019

Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction

Résumé

Since the largest 2014⁻2016 Ebola virus disease outbreak in West Africa, understanding of Ebola virus infection has improved, notably the involvement of innate immune mediators. Amongst them, collectins are important players in the antiviral innate immune defense. A screening of Ebola glycoprotein (GP)-collectins interactions revealed the specific interaction of human surfactant protein D (hSP-D), a lectin expressed in lung and liver, two compartments where Ebola was found in vivo. Further analyses have demonstrated an involvement of hSP-D in the enhancement of virus infection in several in vitro models. Similar effects were observed for porcine SP-D (pSP-D). In addition, both hSP-D and pSP-D interacted with Reston virus (RESTV) GP and enhanced pseudoviral infection in pulmonary cells. Thus, our study reveals a novel partner of Ebola GP that may participate to enhance viral spread.
Fichier principal
Vignette du fichier
viruses-11-00015.pdf (580.68 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01972908 , version 1 (08-01-2019)

Identifiants

Citer

Anne-Laure Favier, Olivier Reynard, Evelyne Gout, Martin van Eijk, Henk P Haagsman, et al.. Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction. Viruses, 2019, 11 (1), ⟨10.3390/v11010015⟩. ⟨hal-01972908⟩
202 Consultations
72 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More