Studies have shown that the use of Phase Change Materials (PCMs) in secondary refrigeration could improve the efficiency of refrigeration systems. In this study, the focus is made on CO 2 hydrate slurry. Despite the demonstration of the interest of such a system, there is a barrier to their industrial development. The work presented in this paper analyses the behaviour of hydrate slurries in an industrial context, here the air conditioning of supermarket, and proposes a multi-performance evaluation of hydrate slurry systems. Starting from the modelling of the rheological and thermal properties of the slurries established by experimental studies in the laboratory, their theoretical energy behaviour in an industrial case can be analysed. In addition, the environmental, economic and operational performance of the refrigeration system are simulated. This innovative architecture using hydrate slurries is compared to systems already implemented in industry such as centralised direct expansion systems using HFC as primary refrigerant and secondary loop using glycol water.