Disrupted placental serotonin synthetic pathway and increased placental serotonin: Potential implications in the pathogenesis of human fetal growth restriction

Abstract : Placental insufficiency contributes to altered maternal-fetal amino acid transfer, and thereby to poor fetal growth. An important placental function is the uptake of tryptophan and its metabolism to serotonin (5-HT) and kynurenine metabolites, which are essential for fetal development. We hypothesised that placental 5-HT content will be increased in pregnancies affected with fetal growth restriction (FGR).
Document type :
Journal articles
Complete list of metadatas

http://hal.univ-grenoble-alpes.fr/hal-02353791
Contributor : Nadia Alfaidy <>
Submitted on : Thursday, November 7, 2019 - 2:30:11 PM
Last modification on : Saturday, November 9, 2019 - 2:04:31 AM

Links full text

Identifiers

Collections

Citation

Suveena Ranzil, Stacey Ellery, David Walker, Cathy Vaillancourt, Nadia Alfaidy, et al.. Disrupted placental serotonin synthetic pathway and increased placental serotonin: Potential implications in the pathogenesis of human fetal growth restriction. Placenta, Elsevier, 2019, 84, pp.74-83. ⟨10.1016/j.placenta.2019.05.012⟩. ⟨hal-02353791⟩

Share

Metrics

Record views

19