Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort

Carole Dufouil 1 Bruno Dubois 2 Bruno Vellas 3 Florence Pasquier 4 Frédéric Blanc 5 Jacques Hugon 6 Olivier Hanon 7 Jean-François Dartigues 1 Sandrine Harston 8 Audrey Gabelle 9 Mathieu Ceccaldi 10 Olivier Beauchet 11 Pierre Krolak-Salmon 12 Renaud David 13 Olivier Rouaud 14 Olivier Godefroy 15 Catherine Belin 16 Isabelle Rouch 17 Nicolas Auguste 18 David Wallon 19 Athanase Benetos 20 Jérémie Pariente 21 Marc Paccalin 22 Olivier Moreaud 23 Caroline Hommet 24 François Sellal 25 Claire Boutoleau-Bretonnière 26 Isabelle Jalenques 27 Armelle Gentric 28 Pierre Vandel 28 Chabha Azouani 29 Ludovic Fillon 29 Clara Fischer 29 Helen Savarieau 30 Grégory Operto 31 Hugo Bertin 32 Marie Chupin 33 Vincent Bouteloup 1 Marie Habert 2 Jean-François Mangin 34 Geneviève Chêne 35
33 ARAMIS - Algorithms, models and methods for images and signals of the human brain
SU - Sorbonne Université, Inria de Paris, ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
Abstract : Background The natural history and disease mechanisms of Alzheimer’s disease and related disorders (ADRD) are still poorly understood. Very few resources are available to scrutinise patients as early as needed and to use integrative approaches combining standardised, repeated clinical investigations and cutting-edge biomarker measurements. Methods In the nationwide French MEMENTO cohort study, participants were recruited in memory clinics and screened for either isolated subjective cognitive complaints (SCCs) or mild cognitive impairment (MCI; defined as test performance 1.5 SD below age, sex and education-level norms) while not demented (Clinical Dementia Rating [CDR] <1). Baseline data collection included neurological and physical examinations as well as extensive neuropsychological testing. To be included in the MEMENTO cohort, participants had to agree to undergo both brain magnetic resonance imaging (MRI) and blood sampling. Cerebral 18F-fluorodeoxyglucose positon emission tomography and lumbar puncture were optional. Automated analyses of cerebral MRI included assessments of volumes of whole-brain, hippocampal and white matter lesions. Results The 2323 participants, recruited from April 2011 to June 2014, were aged 71 years, on average (SD 8.7), and 62% were women. CDR was 0 in 40% of participants, and 30% carried at least one apolipoprotein E ε4 allele. We observed that more than half (52%) of participants had amnestic mild cognitive impairment (17% single-domain aMCI), 32% had non-amnestic mild cognitive impairment (16.9% single-domain naMCI) and 16% had isolated SCCs. Multivariable analyses of neuroimaging markers associations with cognitive categories showed that participants with aMCI had worse levels of imaging biomarkers than the others, whereas participants with naMCI had markers at intermediate levels between SCC and aMCI. The burden of white matter lesions tended to be larger in participants with aMCI. Independently of CDR, all neuroimaging and neuropsychological markers worsened with age, whereas differences were not consistent according to sex. Conclusions MEMENTO is a large cohort with extensive clinical, neuropsychological and neuroimaging data and represents a platform for studying the natural history of ADRD in a large group of participants with different subtypes of MCI (amnestic or not amnestic) or isolated SCCs.
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Submitted on : Monday, January 14, 2019 - 6:05:08 PM
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Carole Dufouil, Bruno Dubois, Bruno Vellas, Florence Pasquier, Frédéric Blanc, et al.. Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort. Alzheimer's Research and Therapy, BioMed Central, 2017, 9 (1), ⟨10.1186/s13195-017-0288-0⟩. ⟨hal-01981009⟩

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