The "in and out" of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate.

Abstract : The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their ability to bind and modulate a multitude of protein ligands. These interactions involve internal oligosaccharide sequences defined by their sulfation patterns. Amongst these, the 6-O-sulfation of HS contributes significantly to the polysaccharide structural diversity and is critically involved in the binding of many proteins. HS 6-O-sulfation is catalyzed by 6-O-sulfotransferases (6OSTs) during biosynthesis, and it is further modified by the post-synthetic action of 6-O-endosulfatases (Sulfs), two enzyme families that remain poorly characterized. The aim of the present review is to summarize the contribution of 6-O-sulfates in HS structure/function relationships and to discuss the present knowledge on the complex mechanisms regulating HS 6-O-sulfation.
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Glycoconjugate Journal, Springer Verlag, 2017, 34 (3), pp.285-298. 〈10.1007/s10719-016-9736-5〉
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http://hal.univ-grenoble-alpes.fr/hal-01461493
Contributeur : Frank Thomas <>
Soumis le : mercredi 8 février 2017 - 11:21:50
Dernière modification le : jeudi 11 janvier 2018 - 06:15:24

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Rana El Masri, Amal Seffouh, Hugues Lortat-Jacob, Romain R Vivès. The "in and out" of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate.. Glycoconjugate Journal, Springer Verlag, 2017, 34 (3), pp.285-298. 〈10.1007/s10719-016-9736-5〉. 〈hal-01461493〉

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