The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex.

Abstract : Lack of regulation of the interaction between the eIF4E/eIF4G subunits of the translation initiation factor complex eIF4F is a hallmark of cancer. The inhibitor 4EGI-1 binds to eIF4E, thereby preventing association with eIF4G through an allosteric mechanism. NMR spectroscopy and MD simulations were used to obtain a mechanistic description of the role of correlated dynamics in this allosteric regulation. We show that binding of 4EGI-1 perturbs native correlated motions and increases correlated fluctuations in part of the eIF4G binding site.
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Angewandte Chemie (English Edition), John Wiley & Sons, 2016, 55 (25), pp.7176-9. 〈10.1002/anie.201603254〉
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http://hal.univ-grenoble-alpes.fr/hal-01341965
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Soumis le : mardi 5 juillet 2016 - 11:04:17
Dernière modification le : lundi 19 février 2018 - 14:34:03

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Nicola Salvi, Evangelos Papadopoulos, Martin Blackledge, Gerhard Wagner. The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex.. Angewandte Chemie (English Edition), John Wiley & Sons, 2016, 55 (25), pp.7176-9. 〈10.1002/anie.201603254〉. 〈hal-01341965〉

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