Exploration of the supramolecular interactions involving tris-dipicolinate lanthanide complexes in protein crystals by a combined biostructural, computational and NMR study.

Abstract : Incorporating in a non-covalent manner lanthanide derivatives into protein crystals has shown to be of prime interest for X-ray crystallography, insofar as these versatile compounds can co-crystallize with proteins through supramolecular interactions, in addition to being strong anomalous scatterers for anomalous-based diffraction techniques. In this paper, the selective affinity of tris-dipicolinate lanthanide complexes for cationic amino-acid residues is explored, using a panel of experimental (X-ray diffraction, NMR titration) and theoretical methods that provides access to an accurate description of the interaction process.
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Article dans une revue
Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2013, 15 (41), pp.18235-42. 〈10.1039/c3cp53671h〉
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Soumis le : vendredi 3 juin 2016 - 10:27:46
Dernière modification le : mercredi 16 mai 2018 - 11:23:25

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Elise Dumont, Guillaume Pompidor, Anthony D'Aléo, Jean Vicat, Loic Toupet, et al.. Exploration of the supramolecular interactions involving tris-dipicolinate lanthanide complexes in protein crystals by a combined biostructural, computational and NMR study.. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2013, 15 (41), pp.18235-42. 〈10.1039/c3cp53671h〉. 〈hal-01326128〉

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