Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.

Abstract : Although the rate of acylation of a penicillin-resistant form of Streptococcus pneumoniae penicillin-binding protein 2x (PBP2x) by ceftaroline is 80-fold lower than that of its penicillin-sensitive counterpart, it remains sufficiently high (k(2)/K = 12,600 M(-1) s(-1)) to explain the sensitivity of the penicillin-resistant strain to this new cephalosporin. Surprisingly, the Actinomadura R39 DD-peptidase is not very sensitive to ceftaroline.
Type de document :
Article dans une revue
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2013, 57 (1), pp.661-3
Liste complète des métadonnées

http://hal.univ-grenoble-alpes.fr/hal-01322362
Contributeur : Frank Thomas <>
Soumis le : vendredi 27 mai 2016 - 09:57:28
Dernière modification le : jeudi 11 janvier 2018 - 06:15:24

Identifiants

Collections

UGA | IBS | CEA | IBS-PNE | DSV

Citation

Astrid Zervosen, André Zapun, Jean-Marie Frère. Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2013, 57 (1), pp.661-3. 〈hal-01322362〉

Partager

Métriques

Consultations de la notice

72