Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.

Astrid Zervosen; André Zapun; Jean-Marie Frère

Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.

Astrid Zervosen ¹ André Zapun ² Jean-Marie Frère

2 IBS - UMR 5075 - Institut de biologie structurale

Abstract : Although the rate of acylation of a penicillin-resistant form of Streptococcus pneumoniae penicillin-binding protein 2x (PBP2x) by ceftaroline is 80-fold lower than that of its penicillin-sensitive counterpart, it remains sufficiently high (k(2)/K = 12,600 M(-1) s(-1)) to explain the sensitivity of the penicillin-resistant strain to this new cephalosporin. Surprisingly, the Actinomadura R39 DD-peptidase is not very sensitive to ceftaroline.

Type de document :

Article dans une revue

Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2013, 57 (1), pp.661-3

Domaine :

Sciences du Vivant [q-bio] / Biochimie, Biologie Moléculaire / Biologie structurale [q-bio.BM]

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http://hal.univ-grenoble-alpes.fr/hal-01322362
Contributeur : Frank Thomas <>
Soumis le : vendredi 27 mai 2016 - 09:57:28
Dernière modification le : lundi 19 février 2018 - 14:34:03

Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.

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Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.

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