Mapping protein conformational energy landscapes using NMR and molecular simulation.

Abstract : Nuclear magnetic resonance (NMR) spectroscopy provides detailed understanding of the nature and extent of protein dynamics on physiologically important timescales. We present recent advances in the combination of NMR with state-of-the-art molecular simulation that are providing unique new insight into the motions on timescales from nanoseconds to milliseconds. In particular, we focus on methods based on residual dipolar couplings (RDCs) that allow for detailed mapping of the protein conformational energy landscape. A novel combination of RDCs with accelerated molecular dynamics allows for the development of ensemble representations of the underlying Boltzmann ensemble.
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Article dans une revue
ChemPhysChem, Wiley-VCH Verlag, 2013, 14 (13), pp.3046-58. 〈10.1002/cphc.201300377〉
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http://hal.univ-grenoble-alpes.fr/hal-01321598
Contributeur : Frank Thomas <>
Soumis le : jeudi 26 mai 2016 - 09:36:11
Dernière modification le : jeudi 11 janvier 2018 - 06:15:24

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Paul Guerry, Luca Mollica, Martin Blackledge. Mapping protein conformational energy landscapes using NMR and molecular simulation.. ChemPhysChem, Wiley-VCH Verlag, 2013, 14 (13), pp.3046-58. 〈10.1002/cphc.201300377〉. 〈hal-01321598〉

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