Fast real-time NMR methods for characterizing short-lived molecular states.

Abstract : The characterization of both the structure and the conformational dynamics of biological macromolecules, namely proteins and nucleic acids, is required for understanding the molecular mechanisms underlying physiological function and disease. Molecular dynamics involves the transient departure from the ground-state structures to populate short-lived excited state conformations that can play important functional roles. Real-time multi-dimensional NMR spectroscopy represents a unique tool for investigating dynamic molecular processes occurring on time scales of seconds or longer, providing atomic-resolution information about short-lived states. In this minireview, we discuss recent progress made in the field of fast real-time multidimensional NMR. The potential of these new methods is illustrated for several biomolecular systems that have recently been studied by fast real-time multidimensional NMR.
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Article dans une revue
ChemPhysChem, Wiley-VCH Verlag, 2013, 14 (13), pp.3059-70
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http://hal.univ-grenoble-alpes.fr/hal-01321580
Contributeur : Frank Thomas <>
Soumis le : jeudi 26 mai 2016 - 09:07:06
Dernière modification le : lundi 19 février 2018 - 14:34:03

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  • HAL Id : hal-01321580, version 1
  • PUBMED : 23857553

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Enrico Rennella, Bernhard Brutscher. Fast real-time NMR methods for characterizing short-lived molecular states.. ChemPhysChem, Wiley-VCH Verlag, 2013, 14 (13), pp.3059-70. 〈hal-01321580〉

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