Impact of human adenovirus type 3 dodecahedron on host cells and its potential role in viral infection.

Abstract : During human adenovirus type 3 (Ad3) infection, an excess of penton base and fiber proteins are produced which form dodecahedral particles composed of 12 pentamers of penton base and 12 trimers of fiber protein. No biological functions have yet been ascribed to Ad3 dodecahedra. Here, we show that dodecahedra compete with Ad3 virions for binding to the cell surface and trigger cell remodeling, giving new insights into possible biological functions of dodecahedra in the Ad3 infectious cycle.
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Article dans une revue
Journal of Virology, American Society for Microbiology, 2012, 86 (9), pp.5380-5
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http://hal.univ-grenoble-alpes.fr/hal-01243638
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Soumis le : mardi 15 décembre 2015 - 11:28:21
Dernière modification le : jeudi 11 janvier 2018 - 06:26:04

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Pascal Fender, Kathryn Hall, Guy Schoehn, G Eric Blair. Impact of human adenovirus type 3 dodecahedron on host cells and its potential role in viral infection.. Journal of Virology, American Society for Microbiology, 2012, 86 (9), pp.5380-5. 〈hal-01243638〉

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